Are you using a No-DVD hack for it?
If so, you may have to put the original .EXE file back in.
Just a thought....
On a personal note, I don't trust 2K Sports anymore at all.
A buddy of mine installed this patch and it completely messed his game up to the point he lost everything. Franchise, player settings, etc.. EVERYTHING!!!!
Therefore I am NOT installing this patch.
I continue to use Beyondo and it works just fine for me.