Game Booster 3 will not do a thing for you. It will not close out your programs. The only real way to do this is to go into your system configuration and turn off all your startup items and some of your services and then restart.
If you want a GREAT program to run games with, check out this one. This is the one I use and have NEVER looked back. And I think it's only about $13.00 for a lifetime subscription with free updates!
Check it out and read about it here: www.gameprelauncher.com
By the way, I have a very high end gaming system and mine will lock up at times when I am at bat and the ball is hit foul deep into the left lower level seats. What I do in Franchise is to save my game after every couple innings. For you people whose game is locking up at the end, why don't you save it in the bottom/top half of the last inning when there's two outs. This way if it locks up you can start it over and hope it doesn't do it again.
I did call 2K Sports tech the other day and talked to them about the lockup issues. I told them to come here and go over to the 2K Sports forum and look at all the issues people were having. They said they were aware of it. The only thing that bothers me is that they have NEVER come out with a PC patch for these baseball games!