Depends on the level on which you're playing and the sliders. On All-Star, I find the PC hits them an awful lot unless sliders are set accordingly. Check out the sliders in the downloads section. The datafile.txt can also help as the power for hot and cold zones can be manipulated in there. Some guys will tell you to hold the swing aiming stick up and in and look for that pitch. I'm not a great HR hitter, but if you know you're guy's hot zone, look for a pitch there and time your aim and swing for optimal contact. Pre-loading the bat is a cheesy way to play regardless, so the timing method, when it works, is more satisfying.