I, too, am having a problem with MVP13. I'm running Windows 7, 64 bit. I had been using MVP12, which was working (most of the time, at least), but I wanted to use the new rosters for this year and on the fourth game of the season (which was supposed to be Danny Salazar pitching), the game crashed and kept crashing, so I figured I'd try MVP13 instead. Here are the steps I followed:
1) Uninstall the game (since I was running MVP12).
2) Reinstall MVP 2005 from discs.
3) Apply Patch 3 and Patch 5.
4) Check to make sure the game is working (it was)
5) Run the MVP13 explodeme from the desktop to the folder "C:Program Files(x86)EA SportsMVP Baseball 2005
6) Open the game in Administrator mode.
The game opens without a problem. The crash comes when you're about to start playing. After going through team select, lineups, pitchers, etc, it gets to the loading screen to actually play. It loads about halfway and then crashes. It doesn't matter what mode or teams - Exhibition, Play Now, Season, Mini Games - They all have the same problem. The game also crashes if I try to click "Create/Edit Player" on the Manage Rosters screen. That makes me think that it's a problem related to the rosters/cyberfaces, somehow. I haven't been keeping up with facepack downloads (at 2 downloads a day, there's too many new ones out there to download in a reasonable amount of time), but I figured that the clean install of MVP13 with no updates should work properly.
It could also be a problem with my computer. After several attempts at MVP13, I uninstalled and tried MVP12 again. But that had the same problem (and a previous install of MVP12 had worked properly). But I figured I'd ask if anyone had any suggestions.