This is true. I had to reinstall Nvidia drivers 340.82. Drivers 344.11 and 344.16 do not work with sweetFX or ENB.
Update: Just delete the d3d9.dll in the main folder of MLB2K12 and you should be able to install 344.11. Any mod with the d3d9.dll will not run in MLB2K12 with this driver.
If you have Reditor II, you can go into roster, appearance, and eye color is 3 column at the top. You can't do it in franchise mode, as Reditor II doesn't recognize franchise only rosters.
Many of the anti-virus programs register a false positive as a virus in these programs. Disable them and re-download and add the programs to your whitelist or exclusion file in your anti-virus program.